Competitive inhibitors change Km or Vmax
“Kompetitives change Km. Also K for POTency (POTassium)”
Parameters of pharmacokinetics
“ADME” Absorption, Distribution, Metabolism, Excretion
Therapeutic index equation
“TITE” Therapeutic Index=Toxic/Effective dose
Drugs with lower therapeutic index values
“Warning These Drugs are Lethal” Warfarin, Theophylline, Digoxin, Lithium
Platelet aggregation is promoted by which receptors
“Aggregates (A for Alpha) Two-rombocytes”
V2 receptors are located in
“Collecting Two-bules”
MAO subtypes are located in
“maoA Anywhere, maoB Brain”
Bethanechol clinical use
“activates Bowel and Bladder smooth muscle”
Neostigmine CNS penetration?
“NeO has NO CNS penetration”
Important features of physostigmine
“PHYxes atropine od and PHreely crosses bbb”
AchE inhibitor poisoning symptoms
“DUMBBEELSS” Diarrhea, Urination, Mydriasis, Bronchospasm, Bradycardia, Exitation of skeletal muscle and cns, Emesis, Lacrimation, Salivation, Sweating
Agonist activity of dopamine on receptors
“DoButAmine” in decreasing order
Beta blockers selectivity
“B1 for A to M (1st half), B2 for N to Z (2nd half)
Beta blockers with intrinsic sympathomimetic activity
“INtrinsic ACtivity” pINdolol, ACebutolol
Tetrodotoxin depolarization or prevention of depolarization
“TEThers gates to each other” prevents depolarization
Drugs causing coronary angiospasm
“Evoke Coronary Artery Spasm” Ergots, Cocaine, Amphetamine, Sumatriptan
Drugs causing cutaneous flushing
“VANNCE” Vanco, Adenosine, Niacin, Nitrates, Ca blockers, Echinocandins
Drugs causing torsades
“antiABCDE” antiArrhythmics (Ia and III), antiBiotics (macrolides), antiCychotics (haloperidol), antiDepressants (tca), antiEmetics(ondansetron)
Drugs causing hyyperglycemia
“These Pills Necessitate Checking Hyperglycemia” Tacrolimus, Protease inhibitors, Niacin, Corticosteroids, Hydrochlorothiazide
Drugs causing SIADH
“Can’t Concentrate Sodium” Cyc, Carbamazepine, Ssri
Drugs causing pancreatitis
“Drugs Causing A Violent Abdominal Distress” Didenosine, Corticosteroid, Alcohol, Valproate, Aza, Diuretics (furosemide, thiazide)
Drugs causing agranulocytosis
“Can Cause Pretty Major Collapse of Granulocytes” Clozapine, Carbamazepine, Ptu, Methimazole, Colchicine, Ganciclovir
Drugs causing aplastic anemia
“Can’t Make New Blood Cells Properly” Carbazepine, Methimazole, Nsaids, Benzenes, Chloramphenicol, Ptu
Drugs causing hemolytics anemia in G6PD deficiency
“hemolysis IS D PAIN” Inh, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Drugs causing megaloblastic anemia
“HyperSegmented PolyMorphos” Hydroxyurea, Sulfa drugs, Phenytoin, Mtx
Drugs causing fat redistribution
“PIG” Protease Inhibitors, Glucocorticoids
Drugs causing hyperuricemia
“Painful Tophaceous Feet Need Care” Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
Drugs causing photosensitivity
“SAT For photo” Sulfonamides, Amiodarone, Tetracyclines, 5-Fu
Drugs causing DRESS and SJS
“ABCS of hypersensitivity” Allopurinol, antiBiotics, antiConvulsants, Sulfa drugs
Drugs causing SLE-like syndrome
“SHIPPP ME” Sulfa drugs, Hydralazine, Inh, Procainamide, Phenytoin, Penicillamine, Minocycline, Etanercept
Drugs causing Parkinson-like syndrome
“rigidity of ARM” Antipsychotics, Reserpine, Metoclopramide
Drugs causing seizures
“with seizures I BITE my tongue” Inh, Bupropion, Imipenem, Tramadol, Enflurane
Drugs causing Fanconi syndrome
“Cause Proximal Tubule Toxicity” Cisplatin, iPhosphamide, Tetracyclines (expired), Tenofovir
Drugs causing interstitial nephritis
“Fancy Pills Starting Interstitial Nephritis” Furosemide, Penicillins, Sulfa drugs, Inhibitor (ppi), Nsaids
Drugs causing pulmonary fibrosis
“My Nose Cannot Breathe Bad Air” Mtx, Nitrofurantoin, Carmustin, Bleomycin, Busulfan Amiodarone
Drugs causing disulfiram-like reaction
“Sorry Pals Cannot Go Mingle” Sulfonylureas (1st gen), Procarbazine, Cephalos (some of them), Griseofulvin, Metro
Drugs causing nephro and ototoxicity
“Amplify Low Volume, Apply Catheters” Ampb, Loops, Vanco, Ags, Cisplatin
CYP450 inducers
“Chronic alcoholics STeal Phen-Phen and NEVer Refuse GReasy CARBs” Chronic alcohol, ST johns wort, Phenobarbital, Phenytoin, NEVirapin, Rifampin, GRiseofulvin, CARBamazepine
Drugs metabolized by CYP450
“Always Think When Outdoors” Antiepileptics, Theophylline, Warfarin, Ocps
CYP450 inhibitors
“SICKFACES.COM” Sodium valproate, Inh, Cimetidine, Ketoconazole, Fluconazole, Acute alcohol, Chloramphenicol, Erythromycin, Sulfonamides, Ciprofloxacin, Omeprazole, Metro
Sulfa drugs
“Scary Sulfa Pharm FACTS” Sulfonamides, Sulfasalazine, Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonylureas

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