Stoelting’s Pharmacology & Physiology in Anesthetic Practice Chapter 2 Basic Principles of Pharmacology

agonist
a drug that activates a receptor by binding to that receptor

antagonist
a drug that binds to the receptor without activating the receptor

a combination of ionic, hydrogen, and van der Waals interactions
How do agonist and antagonists bind?

the sum of the attractive or repulsive forces between molecules
What is van der Waals interactions?

interaction irreversible
What happens if covalently bonded?

Competitive antagonism
Increasing concentrations of the antagonist progressively inhibit the response to the agonist

Rightward displacement or concentration response
What does competitive antagonism cause?

Noncompetitive antagonism
Is present when, after administration of an antagonist, even high concentrations of agonist cannot completely overcome the antagonism?

EC50 the drug concentration giving 50% maximal effect (not binding affinity – the magnitude of a drug effect is not proportional to the proportion of receptors occupied by that drug) a drug with a lower EC50 is more potent (half …

Absorption refers to the movement of drug into the bloodstream, with the rate dependent on the physical characteristics of the drug and its formation. Refers to the passage of drug molecules from the site of administration into the circulation. Active …

Trade name Also known as the drug’s brand name Official name A drug name given by the Food and Drug Administration (FDA) WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my …

Dose response curve shows the relationship between the drug response and the dose Free drug compared to drugs that are protein bound, molecules that can produce a pharmacologic effect WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY …

Regulatory proteins Best-characterized and most receptors, mediate endogenous chemical signals Enzymes Targeted for inhibition WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Transport proteins Na+/K+ ATPase receptor for cardiovascular …

Absorption Uptake of medications for distribution in the body through or across tissues Active ingredient Medicinal ingredient in a pure, undiluted form of the chemical that has effects on body functions WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY …

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