PSY 322 Principles of Pharmacology (Depot Binding)

Depot Binding
Def: the binding of drugs to inactive sites.

Drug Depots
Def: inactive sites where no measurable biological effect is initiated.
1. Includes plasma protein, muscle, and fat.
2. These sites readily bind drugs and can reduce the number of drug molecules that reach the target site.
3. Rapid binding to these sites before reaching the target tissue results in slower onset and reduced effects.

Phase I Depot Binding
Def: the drug arrives at the target site; however, some of the drug will stop at fat tissue along the way and accumulate there for a short amount of time.
1. It will eventually come back into the blood.
2. Usually occurs in less lipid soluble drugs because the drug doesn’t bind to fat tissue; there is a slow onset of drug effects and a long duration.

Phase II Depot Binding
Def: the drug returns to the blood from fat and reaches the target site.
1. The drug has a weaker effect.
2. Usually occurs in very lipid soluble drugs because the drug binds to fat tissue before reaching the target tissue; there is a fast onset of drug effects, but a short duration.

Half-Life
Def: the amount of time required for removal of 50% of the drug in the blood.

Trade name Also known as the drug’s brand name Official name A drug name given by the Food and Drug Administration (FDA) WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my …

Absorption refers to the movement of drug into the bloodstream, with the rate dependent on the physical characteristics of the drug and its formation. Refers to the passage of drug molecules from the site of administration into the circulation. Active …

Pharmacology the study of drugs Drugs any chemical substances that affect biologic systems WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Chemical name determined by chemical structure rarely used …

A process in which a fixed amount of a substance is removed during a certain period, regardless of the total amount in the body. zero-order elimination A property the indicates a material can be dissolved in water. water-soluble WE WILL …

drug substance taken into the body that modifies one or more of its functions. pharmacokinetics How the body deals with a drug, absorbed, distributed, eliminated WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY …

Dose response curve shows the relationship between the drug response and the dose Free drug compared to drugs that are protein bound, molecules that can produce a pharmacologic effect WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY …

David from Healtheappointments:

Hi there, would you like to get such a paper? How about receiving a customized one? Check it out https://goo.gl/chNgQy