1. Includes plasma protein, muscle, and fat.
2. These sites readily bind drugs and can reduce the number of drug molecules that reach the target site.
3. Rapid binding to these sites before reaching the target tissue results in slower onset and reduced effects.
1. It will eventually come back into the blood.
2. Usually occurs in less lipid soluble drugs because the drug doesn’t bind to fat tissue; there is a slow onset of drug effects and a long duration.
1. The drug has a weaker effect.
2. Usually occurs in very lipid soluble drugs because the drug binds to fat tissue before reaching the target tissue; there is a fast onset of drug effects, but a short duration.