Pharmacology: Test Questions and Answers

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Question 1

1. How is the neurotransmitter acetylcholine inactivated at the parasympathetic terminal receptor site?

Answer

A. The the enzyme catechol O-methtransferase (COMT)

B. By the reuptake process

C. By the enzyme cholinesterase

D. By the enzyme monoamine oxidase

E. By the enzyme nicotinase

Question 2

1. You adminster an inhaled bronchodilator that is known to have adrenergic side effects on the heart. What clnical sign should you watch for in your patient?

Answer

A. Tachypnea

B. Bradypnea

C. Tachycardia

D. Bradycardia

Question 3

1. On administering a dose of atropine to your patient, which of the following effects would you expect NOT to see?

Answer

A. Dry mouth

B. Increased mucous production

C. Bronchial dilation

D. Increased heart rate

Question 4

1. Your patient is accidently given a large dose of the parasympathomimetic drug pyridostigmine. What side effects of parasympathetic overstimulation do you expect to see?

Answer

A. Decreased urination

B. Constipation

C. Dry eye and eye irritation

D. Excessive secretion production

Question 5

1. Your patient has bradycardia. What type of drug do you recommend?

Answer

A. Sympatholytic

B. Sympathomimetic

C. Parasympathomimetic

D. Both A and C

Question 6

1. Epinephrine stimulates which of the following receptor sites? (multiple answers)

Answer

A. Alpha

B. Nicotinic

C. Beta-1

D. Beta-2

E. Muscarinic

Question 7

1. Stimulation of which receptor produces blood vessel constriction in the systemic circulation?

Answer

A. Beta-1

B. Beta-2

C. Alpha

D. Muscarinic

E. Beta-3

Question 8

1. Which of the following drugs are sympathomimetic agents?

  1. Salmeterol
  2. Dopamine
  3. Labetalol
  4. Propranolol

Answer

A. 1 and 2

B. 2 and 3

C. 1, 2, 3, and 4

D. 1, 2, and 4 1 points

Question 9

1. A parasympathetic effect is generally the same as which of the following?

Answer

A. Antimuscarinic effect

B. Muscarinic effect

C. Parasympatholytic effect

D. Anticholinergic effect

Question 10

1. Match the appropriate cholinergic effect to each organ site. The answers may be used more than once. Answer Heart Rate Read Answer Items for Question 10 Bronchial smooth muscle Read Answer Items for Question 10 Airway mucous glands Read Answer Items for Question 10 Salivary glands Read Answer Items for Question 10

Answer

A. Decrease.

B. Increased secretion

C. Reduced secretion

D. Dilate or relax

E. Constrict

Question 11

1. Match the following terms to their definitions. Answer Agent causing stimulation of the parasympathetic nervous system Read Answer Items for Question 11 Agent blocking or inhibiting the effects of the parasympathetic nervous system Read Answer Items for Question 11 Agent causing stimulation of the sympathetic nervous system Read Answer Items for Question 11 Drug causing stimulation of a receptor for acetylcholine Read Answer Items for Question 11 Drug blocking a receptor for acetylcholine. Read Answer Items for Question 11 Drug stimulating a receptor for norepinephrine or epinephrine Read Answer Items for Question 11 Agent blocking or inhibiting the effect of the sympathetic nervous system Read Answer Items for Question 11 Alternative term for cholinergic receptor Read Answer Items for Question 11 Alternative term for adrenergic receptor Read Answer Items for Question 11

Answer

A. Cholinergic

B. Anticholinergic

C. Adrenergic

D. Parasympathomimetic

E. Parasympatholytic

F. Sympathomimetic

G. Sympatholytic

H. Cholinoceptor

I. Adrenoceptor

Question 12

1. Adrenergic bronchodilators mimic the actions of:

Answer

A. Norepinephrine

B. Acetylcholine

C. Penicillin

D. Epinephrine

Question 13

1. Short-acting Beta-2 agonists are indicated for:

Answer

A. Reduction of airway edema

B. Relief of acute reversible airflow obstruction

C. Maintenance of bronchodilation

D. Thinning of secretions

Question 14

1. Your patient is diagnosed with persistent asthma. Which typ eof drug would you recommend for maintenance bronchodilation and control of bronchospasm?

Answer

A. Short-acting adrenergic agent

B. Long-acting adrenergic agent

C. Alpha-adrenergic agent

D. Mucolytic agents

E. Short-acting anticholinergic agent

Question 15

1. Your patient presents with post-extubation stridor. You recommend racemic epinephrine for its:

Answer

A. Alpha-adrenergic vasoconstricting effect

B. Short-acting beta-2 adrenergic effect

C. Long-acting beta-2 adrenergic effect

D. Beta-one adrenergic effect

E. Muscarinic parasympathetic effect

Question 16

1. Which of the following statements is correct about the drug Levalbuterol? Answer A. It has identical actions as racemic epinephrine B. It is the single R-isomer of albuterol. C. It is an equal mixture of (R)-isomers and (S)-isomers D. It is thought to be pro-inflammatory and shouldn’t be used in asthma 1 points

Question 17

1. By modifying the catechol nucleus of bronchodilators, what changed regarding the new bronchodilators (resorcinols and saligenins) activity? Answer A. It increased its duration of action B. It made the drug more beta-2 specific C. It made the new drug resistant to inactivation by COMT D. a & c E. a, b, & c 1 points

Question 18

1. Catecholamines should not be given by the following route? Answer A. Inhalation B. Subcutaneous C. Oral. D. Injection 1 points

Question 19

1. Which of the following is not a catecholamine?

  1. Terbutaline
  2. Albuterol
  3. Dopamine
  4. Epinephrine

Answer

A. 1 and 2

B. 1, 3,and 4

C. 1,2 and 3

D. 1, 2, 3 and 4

Question 20

1. Which of the following drugs is a saligenin?

Answer

A. Isoproterenol

B. Metaproteronol

C. Indacatrol

D. Albuterol

E. b and d

Question 21

1. Combivent® is a combination drug including which agents?

Answer

A. Albuterol and salmeterol

B. Salmeterol and ipratropium

C. Albuterol and ipratropium

D. Piralbuterol and flovent

E. Racemic epinephrine and alupent.

Question 22

1. Sympathetic nervous system stimulation produces which of the following effects?

  1. Bronchodilation
  2. Vasoconstriction
  3. Increased salivation
  4. Increased heart rate
  5. Decreased cardiac contractility

Answer

A. 1, 2 and 5

B. 2 and 4

C. 3 and 5

D. 1, 2 and 4

E. 1, 2, 3 and 4

Question 23

1. The most common side effect of anticholinergic bronchodilators is:

Answer

A. Dry mouth

B. INcreased heart rate

C. Wheezing

D. Delirium

Question 24

1. WHich of the following is correct about neta-1 receptor stimulation?

Answer

A. Causes vasoconstriction

B. Provides decongestion of the upper airway

C. Increases heart rate and stroke volume

D. Relaxes bronchial smooth muscle

Question 25

1. Smooth muscle relaxaton most likely occurs as a result of:

Answer

A. A decrease in intracellular cAMP

B. An increase in intracellular cAMP

C. An increase in intracelluar ATP

D. Increased production of phosphodiesterase

E. A inhibition of phosphodiesterase

Question 26

1. Continuous nebulization of inhaled beta agonists has been used for:

Answer

A. Severe asthma

B. Pneumonia

C. Cystic fibrosis

D. Emphysema

E. Pulmonary fibrosis

Question 27.

1. Match the appropriate medication to the classification of adrenergic bronchodilators based on the differences of duration of action. Choices can be used more than once. Answer Formoterol Read Answer Items for Question 27 Epinephrine Read Answer Items for Question 27 Metaproterenol Read Answer Items for Question 27 Levalbuterol Read Answer Items for Question 27 Isoproterenol Read Answer Items for Question 27 Racemic epinephrine Read Answer Items for Question 27 Salmeterol Read Answer Items for Question 27

Answer

A. Ultra-short acting

B. Short acting

C. Long acting

Question 28

1.Which of the following statements is true regarding the drug Indacatrol?

Answer

A. It is indicated as a rescue drug for obstructive lung diseases

B. It is available in nebulizer solution only

C. It inhibits airway inflammation as well as bronchodilation

D. It is the only once-a-day long-acting beta-two adrenergic agent

Question 29

1. What is the common adverse effect of albuterol?

Answer

A. Dilated pupils

B. Dry mouth

C. Tachycardia

D. Tremor

E. Dizziness

Question 30

1. What is the trade name for tiotropium?

Answer

A. Serevent

B. Spiriva

C. Atrovent

D. Brovana

E. Foradil.

Question 31

1. What is the trade name for arformoterol?

Answer

A. Foradil

B. Serevent

C. Spiriva

D. Brovana

E. Xopenex

Question 32

1. The keyhole theory indicates that the larger the side-chain attachment to a catechol base the:

Answer

A. Shorter the duration of action

B. The more rapidly it is metabolized

C. More easily it is broken down by COMT

D. The greater the beta-2 specificity

Question 33

1. In relation to bronchodilators, “rescue” agents refer to:

Answer

A. Prodrugs

B. Controllers

C. Ultra-short acting agents

D. Short-acting agents

Question 34

1. How would you classify the drug tiotropium?

Answer

A. It is an ultra-short acting sympathomimetic bronchodilator

B. It is short acting anticholinergic bronchodilator

C. It is a short acting sympathomimetic bronchodilator

D. It is a long-acting parasympatholytic bronchodilator

Question 35

1. What is the main difference between salmeterol and formoterol?

Answer

A. Formoterol is short-acting and salmeterol is long-acting

B. Formoterol has less side effects than salmeterol

C. Formoterol is more beta-two specific than salmeterol

D. Formoterol has a quicker onset and peak effect than salmeterol

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