Pharmacology: MOA Abx

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MOA: PCN
cell wall biosynthesis

MOA: cephalosporins
cell wall biosynthesis

MOA: carbapenems
cell wall biosynthesis

MOA: vancomycin
cell wall biosynthesis

MOA: quinolones
DNA replication

MOA: Cefuroxime
cell wall biosynthesis

MOA: polymixins
membrane dysruption

MOA: sulfonamide
folic acid metabolism

MOA: trimethoprim
folic acid metabolism

MOA: aminoglycosides
protein synthesis inhibitors

MOA: tetracyclines
protein synthesis inhibitors

MOA: macrolides/erythromycin
protein synthesis inhibitors

MOA: clindamycin
protein synthesis inhibitors

*MOA: tobramycin*
cell wall synthesis inhibitor

MOA: azithromycin
protein synthesis inhibitor

MOA: linezolid
protein synthesis inhibitor

MOA: Tetracycline
protein synthesis inhibitor

MOA: Ciprofloxacin
inhibit bacterial DNA synthesis

MOA: rifampin
inhibit bacterial RNA synthesis

MOA: sulfamethoxazole
inhibit folate synthesis

MOA: trimethoprin
inhibit folate synthesis

Generation of cephalosporins: cefazolin
first

Generation of cephalosporins: cephalexin
first

Generation of cephalosporins: cefuroxime
second

generation of cephalosporins: cefotaxime
third

Generation of cephalosporins: ceftriaxone
third

Concern with cephalosporins:
may cross react with PCN allergy

Concern with aminoglycosides
highly toxic

Concern with gentamycin and tobramycin
toxic (oto, nephro, neuro)

Function of clavulonic acid when added to PCN.
inhibits penicillinase enzyme that is responsible for resistance

Name a drug with prolonged antibiotic effect:
aminoglycosides

List the four mechanisms of drug resistance:
degrade the drug, bind the drug, mutate, efflux pumps (pump drug out of cell)

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy Aminoglycosides gentamicin, streptomycin, tobramycin, neomycin, kanamycin, amikacin (BE CAREFUL WITH THESE “mycins”. They’re not macrolides) Aminoglycosides – gram (-) …

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy Mycobacterium Waxy cell wall (hard to kill) Most common mycobacterium Tuberculosis Viruses Invade cells of host (intracellular parasites) Reproduce …

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy Antibacterial antibiotics that inhibit protein synthesis are? Tetracyclines (bacteriostactic), Macrolides (bacteriostactic), Aminoglycosides (bactericidal) Tetracycline class and uses Antibacterial antibiotic …

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy How does RAS system create Angiotensin II and what are the effects? Liver synthesizes angiotensinogen → renin enzyme converts …

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy Antiprostaglandin drug that inhibits he synthesis of prostaglandin Antipyretic drug that has the ability to lower body temperature WE …

We use cookies to give you the best experience possible. By continuing we’ll assume you’re on board with our cookie policy Adrenergic Agents stimulate the sympathetic nervous system and induce symptoms characteristic of the fight-or-flight response Sympathomimetics Adrenergic Agents WE …

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