Pharmacology I Phenylephrine and Clonidine

a1 agonist, yes, no
Receptors for Phenylephrine? Is it orally active? can it be metabolized by comt?

vasoconstriction, decongestant, mydriasis, reflex dependent bradycardia
Therapeutic uses of phenylephrine? 4 items

excessive vasocontriction, rebound hyperemia, contraindicated in CVA and aneurysm
Adverse effectrs of phenylephrine? 3 items

a2 agonist, imidazoline receptors
Recetpor for clonidine? 2 items

presynaptic inhibition of release, central inhibition of symp, stimulates parasymp….yes
How does clonidine work (3 thangs)? is it orally active?

antihypertensive, supplement anesthesia, drug withdrawal, ADD
Therapeutic effects of clonidine? 4 thangs

reduce diarrhea in autonomic diabetic neuropathy, tourettes, hyperhidrosis, restless leg, ulcerative colitis
Off label uses of clonidine? 5 thangs

guanfacine, guanabenz
Name other a2 agonists with no imidazoline activity (2)

sedation and caution in diabetics
What is side effects of the other a2 agonists?

Name Clonidine Drug Class Classification: selective alpha2 adrenergic agonist Pregnancy Category: C WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Contraindications tablets should not be used in patients with …

clonidine generic Catapres clonidine drug class Alpha-2 specific adrenergic agonist WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Clonidine indications Mild to moderate hypertension. Attention-deficit hyperactivity disorder (ADHD) Epidural: …

Cholinergic Agonist, mech of action inhibit acetylcholine synthesis, storage and release, Muscarinic and nicotinic cholinergic receptor agonists, acetlycholinesterase inhibitors Cholinergic agonists effects, endothelial release NO -> vasodilation WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU …

Regulatory proteins Best-characterized and most receptors, mediate endogenous chemical signals Enzymes Targeted for inhibition WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Transport proteins Na+/K+ ATPase receptor for cardiovascular …

What components of the sympathetic nervous system are innervated by cholinergic fibers? adrenal medulla and sweat glands ACh acts are 2 types of receptors: nicotinic and muscarinic. What types of receptors are these? nicotinic ACh receptors are Na+/K+ channels muscarinic …

What does it mean that DR interactions are concentration dependent? It means that as the concentration of the drug increases the % of receptors bound increases What does it mean the DR interactions are saturable? At a certain concentration 100% …

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