Pharmacology Drugs: Chapter 21⇒ [Benzodiazepines]: Alprazolam

Name
Alpazolam

Drug Class
Sedative-hypnotic: benzodiazepine
Xanax
Pregnancy Category: D

Contraindications
Respiratory depression, acute alcohol intoxication, psychotic reactions, recent respiratory depressants, hypersensitivity
Older adults, sleep apnea, renal or liver dysfunction, depression, suicidal ideation, drug abuse

Drug-Food-Lab Interactions
Drug: Decreases respiration with alcohol, CNS depressants; azole antifungals (ketoconazole), antibiotics (erythromycin), aprepitant, cimetidine, diltiazem, verapamil increase blood levels of alprazolam; rifabutin, rifampin, cortisone, phenytoin decrease blood levels; alprazolam increases digoxin and lithium levels
Food: Grapefruit increases alprazolam levels; green tea decreases alprazolam effects

Pharmacokinetics
Absorption: PO: 90% absorbed from GI tract
Distribution: PB: 80%-90%
Metabolism: : 11-16 h
Excretion: In urine as metabolites

Pharmacodynamics
PO: Onset: UK
Peak: 1-2 h (immediate-release); 9 h (extended-release); 1.5-2 h (disintegrating tablet)
Duration: UK

Therapeutic EffectsUses
To Treat Anxiety and Panic Disorders

Mode of Action: CNS depression, binds receptors in limbic system and reticular formation, increases GABA to GABA receptors, shift of chloride ions leads to less excitability and stabilizes neuronal membranes

Side Effects
Lethargy, drowsiness, dizziness, headache, constipation, memory impairment, increased appetite, blurred vision, decreased libido, paradoxical reactions

Adverse Reactions
Depression, impaired coordination

What are the indications for Anti-Anxiety Benzodiazepines? Reduce anxiety, Induce sedation, Relax Muscles, Inhibit Convulsions, Treat A ETHOL and drug withdrawal symptoms, Safer than Sedative-Hypnotics What are the reactions for the Anti-Anxiety Benzodiazepines? Sedation, Drowsiness, Ataxia, Dizziness, Irritability, Blood dycrasias, …

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Drug classification Anxiolytic – benzodiazepine Safe dose range PO 0.25 mg – 0.5 mg not to exceed 4 mg/day WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Pharmacological action …

What do Psychotropic Drug treat? Anti anxiety, Anti depressant, anti psychotic Sedative Drugs drug that produce a relaxing,calming effect but usually does not cause sleep WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY …

Alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), temazepam (Restoril) Notes – Benzodiazepine – schedule IV controlled substances Alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), temazepam (Restoril) Indications (Table 34-2) a. anxiety (drug of first choice) b. panic disorder c. insomnia d. seizures …

Name Clonidine Drug Class Classification: selective alpha2 adrenergic agonist Pregnancy Category: C WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Contraindications tablets should not be used in patients with …

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