Pharmacology Chapter 15 – Drugs for the Treatment of Gastrointestinal Disorders

What are the two gastrointestinal disorders?
Gastroesophageal reflux disease (GERD) and ulcers

What is the most common GI disease in the U.S.?
“Heartburn” (GERD)

What is it called when stomach contents flow backward through the cardiac sphincter into the esophagus?
GERD

(True/False) The esophagus does not tolerate the stomach’s acid well, so irritation, inflammation, and erosion can occur.
True

How can symptoms of GERD be decreased?
By eating smaller meals more frequently, sleeping with head raised, and not eating for 4 hours before bed

What reduces or eliminates acid?
H2 blockers

What is used for acute relief of GERD symptoms?
Antacids

What are lesions in the stomach or small intestine caused by Helicobacter pylori?
Ulcers

What are drugs used to treat GI diseases?
H2 blockers, proton pump inhibitors, mixed antiinfective therapy, antacids, laxative, antidiarrheal, and antiemetic

What are some H2 blockers?
Cimetidine (Tagamet) – more side effects and Famotidine (Pepcid), Ranitidine (Zantac) – both with less side effects

What are the instructions for H2 blockers?
Take with meals and at bedtime

What are some adverse reactions of H2 blockers?
CNS effects (slurred speech, delusions, confusion)

What GI drug inhibits gastric secretions, used in combination with antibiotics, and acute treatment and management of GERD?
Proton pump inhibitors

What treats symptoms of ulcers and acute gastritis and neutralizes hydrochloric acid in the stomach?
Antacids

What do emetics do?
Induce vomiting, used for drug overdoses, ipecac, and abused by bulimics

What is used to treat vomiting associated with motion sickness, used to control severe nausea, pregnancy, drugs, infections, or radiation therapy?
Antiemetics

What involves all layers of the intestinal wall, involves the whole intestine (mainly the colon), involves the rectum and the distal colon, and does not involve the small intestine?
Crohn’s disease and ulcerative colitis

Antacids neutralizing gastric hydrochloric acid and are widely available in many over-the-counter (OTC) preparations for the relief of indigestion, heartburn, and sour stomach Antiulcer drugs are use to relive symptoms association with ulcers and to promote healing WE WILL WRITE …

Peptic Ulcer drugs 1. Histamine2-receptor antagonists 2. Proton pump inhibitors 3. Mucosal protectatnts 4. Antacids 5. Prostaglandin E analogs 6. Antibiotics Histamine2-Recepeter Antagonists treats – Gastric and duodenal ulcers – Heartburn, dyspepsia – Erosive esophagitis – GERD – Aspiration pneumonitis …

drug therapy for peptic ulcers histamine 2 receptor antagonist( Zantac) proton pump inhibitors( Prilosec) mucosal protectant antacids prostaglandin e analogs( misoprostol cytotec) antibiotics( amoxicillin) drug therapy for nausea serotonin antagonist( Zofran) antihistamine prokinetic(Reglan/ metoclopramide) WE WILL WRITE A CUSTOM ESSAY …

*Drugs for GERD and Ulcers*: Drugs that block gastric acid 1) H2 blockers 2) Anticholinergic drugs 3) Prostaglandin analogues 4) Proton pump inhibitors Other: Digestive aids, pepto-bismol, anti-nausea 1) Histamine (H2) Receptor blockers *Cimetidine* -histamine increases gastric acid release. -blocking …

alimentary canal another name for the gastrointestinal tract calculus stone commonly formed from calcium found in the gall bladder or kidneys WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample …

Overview This chapter describes drugs used to treat four common medical conditions involving the gastrointestinal (GI) tract: 1) peptic ulcers and gastroesophageal reflux disease (GERD); 2) chemotherapy-induced emesis; 3) diarrhea; and 4) constipation. Many drugs described in other chapters also …

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