Paramedic Pharmacology – Diphenhydramine

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Brand
Benadryl

Class
Antihistamine, anticholinergic

MOA
Binds and blocks H1 histamine receptors, decreased capillary permeability, decreased vasodilation, and reduces bronchospasm.

Indications
Allergic reactions and anaphylaxis

Contraindications
Acute asthma (thickens bronchial secretions).
**caution in presence of CNS depressants (alcohol/drugs), cardiac hx, and known sensitivity.

Adverse Reactions
Drowsiness, dizziness, headache, excitable state (paradoxical reaction in some children), hypotension, palpatations, dysrhythmias, anaphylaxis, wheezing/thickening bronchial secreations, chest tightening, blurred vision, dry mouth, N/V, diarrhea, sedation, and seizures.

Dose (Adult)
50mg slow IV (infused over 2-3 min) or IM

Dose (Peds)
1mg/kg slow IV (infused over 2-3 min) or IM, max dose 50mg

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