Paramedic Pharmacology – Atropine Sulfate

Brand name for Atropine Sulfate

Class of Atropine Sulfate
Anticholinergic (antimuscarinic)

MOA of Atropine Sulfate
Competes wuth acetylcholine at the site of the muscarinic receptor. Receptors affected (most to least sensitive) include salivary, bronchial, sweat glands, eyes, heart, and GI tracts.

Indications of Atropine Sulfate
Symptomatic bradycardia, asystole, nerve agent exposure, organophosphate poisoning, or refractory bronchospasm.

Contraindications of Atropine Sulfate
AMI, myasthenia gravis, GI obstruction, closed-angle glaucoma, known sensitivity to atropine/belladonna, alkaloids, or sulfates.

Adverse Reactions of Atropine Sulfate
Decreased secretions, dry mouth, intense facial flushing and hot skin temperature, blurred vision or pupil dilation and photophobia, tachycardia, and restlessness, May cause paradoxical bradycardia if dose administered is too low or given too slowly.

Dose (Adult) for Atropine Sulfate
Symptomatic Bradycardia: 0.5mg rapid IVP q 3-5 min. **SINGLE MAX DOSE of 3mg.

Asystole: 1mg IV/IO q 3-5 min **SINGLE MAX DOSE of 3mg.

Nerve Agent/Organophosphate Poisoning: 2-4mg rapid IVP q 20-30 min until secretions are diminished.

Dose (Peds) for Atropine Sulfate
Symptomatic bradycardia: 0.02mg/kg rapid IVP, minimum dose of 0.1mg, maximum single dose 0.5mg.

Organophosphate/nerve agent Poisoning: 0.05mg/kg rapid IVP q 5-20 min until secretions are diminished.

atropine sulfate drug action Acts by selectively blocking all muscarinic responses to acetylcholine (ACh), whether excitatory or inhibitory. Selective depression of CNS relieves rigidity and tremor of Parkinson’s syndrome. Antisecretory action (vagolytic effect) suppresses sweating, lacrimation, salivation, and secretions from …

Adenosine First drug for most forms of stable narrow-complex SVT; effective in terminating those due to reentry involving AV node or sinus node Amiodarone Because its use is associated with toxicity, it is indicated for use in patients with life-threatening …

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ADENOSINE indications for use *First drug for most forms of stable narrow complex SVT. *Effective in terminating those due to reentry involving AV node or sinus node. AMIODARONE indications for use *VF/pulseless VT unresponsive to shock delivery, CPR, and a …

Activated Charcoal Class: Adsorbent Indications: Most oral poisonings and medication overdoses Contraindications: Comatose pt’s + after injestion of corrosives, caustics Dosage: Adult: 1-2 g/kg PO Pediatric: 1-2 g/kg PO Adenosine ( Adenocard ) Class: Endogenous nucleotide Indications: Conversion of PSVT …

Activated Charcoal (Actidose, Insta-char) Class: Absorbent Actions: Adsorbs toxins by chemically binding and prevents gastrointestinal adsorption. Route: Oral Indications: Poisoning following emesis or when emesis is contraindicated. Contraindications: None in severe poisoning. Precautions: Should only be administered following emesis, in …

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