15 mg po daily hs; may titrate to 45 mg po daily hs

an antidepressant that antagonizes presynaptic α2-adrenergic auto- and hetero-receptors that are responsible for controlling the release of norepinephrine and serotonin (5-HT). It is also a potent antagonist of postsynaptic 5-HT2 and 5-HT3 receptors. The net outcome of these effects is increased noradrenergic activity and enhanced 5-HT activity, especially at 5-HT1A receptors. This unique mechanism of action preserves antidepressant efficacy but minimizes many of the adverse effects common to heterocyclic antidepressants and SSRIs.

Dose Adjustment Hepatic
Increase dose slowly as needed and

Dose Adjustment Renal
CrCl <40 mL/min, increase dose slowly as needed and tolerated

Hypersensitivity to mirtazapine; concurrent
MAOI use

Black Box Warnings
Suicidality; not for use in children

Fluoxetine, fluvoxamine, linezolid, MAOIs, olanzapine, tramadol, venlafaxine
Increased risk of serotonin syndrome; Avoid concomitant use

Common Adverse Reactions
Constipation, increased appetite, somnolence,

Rare but Serious Adverse Reactions
Neutropenia, suicidal thoughts

Key Patient Counseling Points
Orally disintegrating tablet blister pack should be opened with dry hands and placed on tongue; no water is needed; tablet should be used immediately after removal from package; once removed, it cannot be stored. Avoid activities requiring mental alertness until drug
effects are realized. Report worsening depression, suicidal ideation, or unusual changes in behavior. Do not drink alcohol while taking this drug.

Clinical Pearls
Safety and effectiveness in pediatric patients have not been established. Use with caution in elderly patients who may be more susceptible
to adverse effects. Medication guide required at dispensing

Class Therapeutic: antidepressants Pharmacologic: Tetracyclin antidepressants Therapeutic Effect Major depressive disorders, general anxiety, PTSD WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Contraindications MAO inhibitors, h/o seizures, h/o suicide …

Drug treatment is only advised for severe mental conditions (Westen, 2006). There are general classes of drugs typically prescribed for mentally-disturbed patients. These include anxiolytics or tranquillizers for anxiety, antipsychotics for psychotic symptoms, anti-epileptics for epilepsy, and antidepressants for depression …

examples of MAOIs phenelzine sulfate (nor Dale), isocarboxazid (Marplan), tranycypromine (Parnate) side effects of MAOIs hypertensive crisis when taken with foods containing tyramine. Photosensitivity, weight gain, sexual dysfunction, orthostatic hypotension. WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC …

Sedatives/Hypnotics Nembutal Sedatives/Hypnotics Phenobarbital WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my sample Sedatives/Hypnotics Seconal Sedatives/Hypnotics Ambien Sedatives/Hypnotics Doral Sedatives/Hypnotics Dalmane Sedatives/Hypnotics Restoril Sedatives/Hypnotics Halcion Sedatives/Hypnotics Sonata Sedatives/Hypnotics Lunesta Sedatives/Hypnotics …

Teaching with antidepressant medication therapy relief is not immediate and it may take several weeks to reach therapeutic benefits Main groups of antidepressant medication tricyclic antidepressants selective serotonin reuptake inhibitors monoamine oxidase inhibitors atypical antidepressants WE WILL WRITE A CUSTOM …

Generic name- Trazodone Trade name- Desyrel Classification- Antidepressant Routes of administration- PO Dosage- 25-100mg at bedtime Actions-Alters the effects of serotonin in the CNS Theraputic effects-Antidepressant action, which may develop only over several weeks Contraindications-Hypersensitivity, recovery period after MI, concurrent …

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