Is It Safe to Mix Benadryl and Alcohol?

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Patients suffering from allergies often complain of repeated sneezing, excruciating skin itching, blearing eyes and a runny nose. To reduce the signs of allergy or spring catarrh and improve the quality of life, antihistamines are used. Diphenhydramine, known as Benadryl, is a widely used remedy, as it is freely available in pharmacies and grocery stores.

Like any drug, Benadryl is not harmful, and the patient must strictly follow the rules of treatment. Non-compliance with drug therapy can result in overdose and a negative secondary reaction. Mixing Benadryl and alcohol can lead to serious disorders. Benadryl and alcohol suppress the function of the central nervous system. The combination of compounds can critically suppress your CNS.

Sleeping disorders

Mixing diphenhydramine and alcohol can lead to serious awareness-inducing and psychogogic effect. Therefore, a person will feel confused and anxious. This will reduce the performance problems with undistracted attention and self-control. Benadryl can alter the effect of sleep, drugs and other remedies, so take Benadryl to treat colds or allergies only.

Driving warning

Drinking alcohol significantly reduces the speed of response and provokes risky behavior. Therefore, it is strictly forbidden to drive in a state of intoxication. Benadryl and wine worsen the effect of alcohol on a much longer and unpredictable period. Alcohol and Benadryl reduce purposefulness and increase the likelihood of accidents and injuries.


If you still think can you take Benadryl with alcohol without any risks, consider that this combination can lead to insanity and cut your attention. The result of uncontrolled actions may be a threat to life. In addition, a cocktail of Benadryl and alcohol might be habit-forming.

Senior age problems

Benadryl with alcohol is especially dangerous for older patients. This can lead to impaired motor function and increases the chances of a heart attack. Patients suffering from asthma or COPD are at high risk of ventilatory depression or interruption.

Severe effect

People have different resistance to a combination of alcohol and diphenhydramine. Some people have no signs of side effects, some complain of serious disorders. Remember that a combination can have a very negative effect on your physical condition. Alcohol and Benadryl can lead to internal bleeding and cardiorespiratory arrest. A high dose of Benadryl with alcohol can shut down your CNS and lead to your death.


Never drink alcohol after Benadryl or any medications and vice versa. Ask your GP about alcohol in your prescribed medications if you are taking any. Some drugs may contain alcohol up to 10 percent. Read the labels and medication guides carefully. It might be a good idea to ask your GP or pharmacist about the interaction of Benadryl with other drugs and nutritional supplements.

Briefly about Benadryl

Diphenhydramine is an allergy and itch relief over-the-counter compound. Benadryl and other antihistamines reduce the effect of histamine on the main chemical trigger and mediator of allergy. Antihistamines are used to relieve allergy symptoms. It is recommended to use the medicine for a short time until signs appear. It is forbidden to give Benadryl to children under 2 years of age, as this can cause respiratory arrest and death.

What to do if you mixed alcohol and Benadryl?

  • If you complain about dry mouth, use sugarless caramel or gum, using chipped or cold water. Do not take other remedies.
  • If you feel sleepy, take a nap. The effect of the combination will disappear by itself.
  • In case of nausea, vomiting, dizziness, or breathing disorders, consult a general practitioner or seek medical help immediately.


Diphenhydramine is an antihistamine prescribed for short-term use. Try not to drink alcohol during treatment. Mixing drugs with alcohol can lead to life-threatening health disorders and behavior problems. Benadryl and alcohol make driving extremely risky. Turn to GP if you have additional uncertainties regarding the mixing of alcohol and diphenhydramine. So can you take Benadryl with alcohol? The answer is certainly not.


  • Dill, Wesley A., and Anthony J. Glazko. “BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL) I. CHEMICAL DETERMINATION OF DIPHENHYDRAMINE.” Journal of Biological Chemistry 179.1 (1949): 395-401.
  • Sainz, Anthony A. “The treatment of drug and alcohol withdrawal effects with thorazine.” The Psychiatric Quarterly 31.1-4 (1957): 275-284.
  • Aakhus, Angela E., and Erin M. Warshaw. “Allergic contact dermatitis from cetyl alcohol.” Dermatitis 22.1 (2011): 56-57.

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