Histoplasma Capsulatum: fungal pneumonia

-clearning and burning wood from a field that served as a bird roost, was laden with bird feces

-asymptomatic infections occur but calcified tubercle like lesions can be observed on X-rays primarily in visceral organs

Agent is:
facultative intracellular found in macrophages

*systemic disease is characterized by massive parasitism of macrophages*

Progressive disseminated disease in adult
-Darling’s Disease
symptoms similar to miliary tuberculosis and lesions in:
~liver, spleen, adrenals

-destruction of adrenal can result in *Addison’s Disease*: if untreated death occurs in 10 months

Progressive systemic disease in infant
-unrelenting fever and hepatosplenomegaly
-if untreated: death in 6 weeks

-microscopic exam of appropriately stained tissue samples reveals:
~rounded to oval yeast forms in macrophages from pulmonary or extra-pulmonary tissue (bone marrow)

1) Complement fixation: test with histoplasmin (mycelial antigen) and whole yeast cell antigens (histolyn)

2) Immunodiffusion test: Precipitin bands form to H and M antigens:
~H antigen positive: occurs in active histoplasmosis, indicates primary disease
~M antigen positive: occurs in acute or chronic disease

3) RIA test for H. capsulatum polysaccharide antigen in serum or urine

4) ELISA assay using man to H. capsulatum 69–> 70 kDa antigen present in serum

-Amphotericin B lipid formulations followed by oral itraconazole


Yeasts Unicellular; have buds called *blastoconidia*; divide by budding; colonize plates like bacteria Molds Multicellular; have filaments called *hyphae* to replicate/spread; “hairy” growth on plates -Part of mycelium involved in gaining nutrients=vegetative mycelium -Part of mycelium involved in growth and …

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dimorphic fungi most common etiologic agents of pulmonary infection by fungi in healthy hosts blastomyces, histoplasma, coccidiodes, paracoccidiodes common pulmonary dimorphic fungi WE WILL WRITE A CUSTOM ESSAY SAMPLE ON ANY TOPIC SPECIFICALLY FOR YOU FOR ONLY $13.90/PAGE Write my …

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Acute Bronchitis – Patho Inflammation of the bronchi acute or chronic Inflammatory response causes capillaries to dilate and fluid to escape resulting edema of mucosal lining Increased exudate production Ciliated epithelium damage impairs ciliary funciton Acute Bronchitis – Manifestations Non-production …

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