Elsevier Pharmacology

A nephrotoxic medication

An elevated Blood Urea Nitrogen (BUN) can be an early sign of toxicity

The BUN of a healthy adult
10 to 20 mg/dL or 3.6 – 7.1 molecule/L

The healthy hematocrit range in a healthy adult
40 to 52

The expected range of the WBC count in a healthy adult
5,000 to 10,000

The expected calcium range for a healthy adult
9.0 to 10.5 or 2.25 to 2.75 mmol/L

Patient reports lumbar pain ten mins after initiation of blood transfusion, what should nurse do?
Stop the transfusion; this is a sign of an acute hemolytic transfusion reaction indicating recipients blood is incompatible

Actions to take for an acute hemolytic transfusion reaction
1) Stop the transfusion
2) Normal saline should be infused to the line patent to maintain blood volume

Monitor to evaluated effectiveness of carbamazepine in the management of a client’s trigeminal neuralgia
Pain Intensity

Administered to control pain by reducing transmission of nerve impulses in clients with trigeminal neuralgia

Liver function is monitored to detect adverse reactions to this drug, to determine effectiveness

Nitroglycerin sublingually
Relieves anginal pain, not myocardial infarction pain

Opioid analgesic that acts on the central nervous system by a sympathetic mechanism

Decreases left ventricular after load, thus decreasing myocardial oxygen consumption

Oxygen administration
Elevates arterial oxygen tension, potentially improving tissue oxygenation, but will not relieve the pain

Antidysrhythmic, not an analgesic

Bile acid sequestrants also known as bile acid binding resins
Vitamins A, D, E, K decrease the absorption of

Anemia and leukopenia are adverse reactions


Has been shown to inhibit metabolism of phenytoin, which results in an accumulation of phenytoin in the body

Potentiates the anticoagulant effect of heparin

Seizures do not have a significant effect on the metabolism of this drug

When administering albumin intravenously
Intravenous albumin increases colloid osmotic pressure, resulting in a pull of fluid from the interstitial compartments to the intravascular compartment

Antioxidants in cranberry juice may inhibit the mechanism that metabolizes warfarin, causing elevations in the international normalized ration, resulting in hemorrhage

Ranitidine (Zantac)
Inhibits histamine at H2 receptor sites in the stomach, resulting in reduced gastric acid secretion

Reduces, rather than neutralizes, gastric acidity

Docusate sodium action
Promotes the drawing of fluid into the stool, which softens the feces

Patients with liver disease
At risk for hypoglycemia

A client who has schizophrenia is receiving a phenothiazine antipsychotic medication
Yellow sclera are a sign of toxicity that has damaged the liver and necessitates withholding the drug

A client who has schizophrenia is receiving a phenothiazine antipsychotic medication
Abnormal movements of involuntary muscle groups, particularly of the face, mouth, tongue, fingers, and toes can occur after a prolonged period of dopamine blockade

Can potentiate the effect of oral hypoglycemic, causing hypoglycemia

The blood glucose level should be monitored more frequently

A daily fluid intake of 2500 to 3000 mL will limit the risk of developing renal calculus

Should be taken with milk or food to decrease gastrointestinal irritation

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