Dilaudid vs. Oxycodone: Which Is Better for Pain?

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Dilaudid vs Oxycodone

Opioids are a class of drastic painkillers that are administrated only on prescription. Due to the intake of opioids the pain impulses are blocked and the change in the affective response to pain is observed. The other impacts include euphoria, a sense of slackening and feeling of bliss. The most substantial disadvantage of opioids is the development of mental and physical dependence.

Hydromorphone vs oxycodone

Without going into details, Oxycodone and Dilaudid (hydromorphone hydrochloride) refer to narcotic analgesics. Pain medications Dilaudid and Oxycodone are administrated for oral supplementation in pills and as injecting grout. Both meds are available in long-term dosage forms to reduce the intake frequency, and to cut the risks of unpredictable reactions.

Dilaudid and Oxycodone are rather potent pain relievers administrated only by prescription. Sweating, vertigo, sedation, obstipation, skin itch, pasties, nausea are count in the common adverse effects. Dilaudid and OxyContin side effects that raise fears are slowed and/or troubled breathing.

It is it is strictly prohibited to mix alcoholic drink or other CNS tranquillizers with Dilaudid and Oxycodone. Such combination tends to end with extreme sedation, respiratory compromise, coma, and death. The intake of Dilaudid or OxyContin might lead to misuse and narcotic dependence.

How strong is Dilaudid?

Dilaudid is an opioid agonist. Hydromorphone causes pain relief by locking the recessed pathways. Dilaudid is prepotent analgetic than Oxycodone. The remedium has been approved by the FDA since 1984. Other brand names: Dilaudid, Dilaudid-5, Exalgo, Palladone.  Painkilling effect lasts 3-5 hours. Dilaudid is habit-forming so take this drug just like prescribed and follow all inserts on the pharmaceutical label.

Hydromorphone is approximately 5 times stronger than morphium if administrated in equal doses by weight. Hydromorphone directly affects the expiratory centre and therefore might provoke respiratory depression. Due to the excitation of the chemoreceptors of the emetic center in the posterior region of the medulla oblongata, Dilaudid may provoke sickness and honk. As a result of slowing down the motility of the gut constipation occurs. Hydromorphone cuts the blood pressure so it may trigger critical hypotension in patients who suffer LP or take in antihypertensive drug.

Dilaudid is not recommended for people with seizures, brain injuries, asthma, obstructive sleep apnea syndrome, mood or mental disorders, depression, liver failure.

What is stronger than Dilaudid?

Dilaudid belong to the Opioids of stage II. Painkiller is suggested to ease a moderate pain syndrome. Opioids of stage III include Phentanyl, Pentazocine, Buprenorphine.

How strong is Oxycodone?

Developed in 1916 in Germany Oxycodone is a semi-synthetic opioid inhibitor and antitussive drug akin to Morphium, Methyllnorphine, and Hydrocodone. It is on the list of Schedule II controlled substances. The med shows a moderate analgesic effect. It is more effective for acute pains. OxyContin affects the human brain to modify the sensibility and repercussion of your body to anguish. An abuse-deterrent mix with Naloxone is ordered in control-release tablets.

Never take Oxycodone in large rate or for longer course than instructed by the GP. The violation of the regimen may result in an overdosage or fatal outcome. Other non-narcotic analgesics (e.g., Aminacetophen, Ibuprofen) can be taken with Oxycodone. Oxycodone is counter-indicative for individuals with asthma or any other breathing dysfunction, addiction or mental disorder, liver or kidney problems or functional disturbance of the biliary passage, pancreas, or thyroid gland.

OxyContin, Roxicodone, Eucodal, Nucodan and Oxecta are the brand names.


The long-standing practice of using oral form every 4 hours is based not on clinical studies, but on the characteristics of the pharmacokinetic profile (max is less than 1 hour, half-life is 2-3 hours, duration of action is about 4 hours). Pain medications dosing is determined in accordance with the patient’s needs, weight, and the pharmaceutical form and presentation. It is better to step up the doses slowly from the minimum to the one that show the desired effect. Instant release pills are taken every 4-6 hours. The rate of administration should be set up or changed only by the doctor.

Dilaudid and Oxycodone Side Effects

Frequent adverse drug reactions:

  • vertiginousness;
  • spatial disorder;
  • sedation;
  • sickness and vomiting;
  • obstipation;
  • sweating;
  • flushing;
  • skin itch;
  • dry mouth;
  • headache;
  • lesion;
  • faintness.

Serious harmful impact:

  • Trouble breathing.
  • Respiratory failure.
  • Mood changes and depression.
  • Abnormal heartbeats and heart attack.

Oxycodone and Dilaudid are habit forming. Long-term course could lead to resistance, non-response, adjustment to the opioid or mental and physical dependability. Sudden withdrawing provokes sings of withdrawal. Turn to your GP how to discontinue the use of the drugs accurately. Cut off the dosage slowly to lessen the risk of rebound syndrome. OxyContin and Dilaudid corrupt the rationality and impair the ability to drive a machine.

Pregnancy and breastfeeding

The clinical studies to identify the drug safety and efficacy of Hydromorphone and Oxycodone during pregnancy haven’t been conducted. A child born to mother who was taking opioids for a long course may manifest ventilatory depression or abstinence. Small amounts of opioids are exported into mother’s milk, therefore painkillers are not recommended for nursing women.


BBW is put in the package information leaflet of Hydromorphone. It indicates that researches have discovered the opioid have fatal adverse reactions. Opioids are addictive if taken continually and a person can become dependent on the meds.


Dilaudid compared to Oxycodone is more potent in equivalent doses. OxyContin is suggested for breakthrough pain, while Hydromorphone is better for prolonged pain. Anguish has a detrimental and exhaustive influence on the welfare of patient. When opioids are taken according to the prescription and not for long, analgetics grant much-needed ease.


  • Katzung, Bertram G., Susan B. Masters, and Anthony J. Trevor, eds. “Basic & clinical pharmacology.” (2004).
  • Lurcott, Gregg. “The effects of the genetic absence and inhibition of CYP2D6 on the metabolism of codeine and its derivatives, hydrocodone and oxycodone.” Anesthesia progress 45.4 (1998): 154.
  • Razaq, Mohammad, Madelyn Balicas, and Nagender Mankan. “Use of hydromorphone (Dilaudid) and morphine for patients with hepatic and renal impairment.” American journal of therapeutics14.4 (2007): 414-416.

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