prevent disabling deformities
Long term glucocticoid therapy
poor calcium intake
chronic alcohol abuse
greater osteoclast activity
Disease-modifying anti rheumatic drugs (DMARDs)
-initially given with NSAIDs
-slow onset of therapeutic effects (weeks)
-May discontinue when therapeutic effects are reached.
DMARDs II- Major biologic
DMARDs III- Minor non-biologic and biologic
Can slow stop progression of RA
Treat cancer in large doses
Bone marrow suppression
increased risk of infection
Also given with a weekly folic acid supplement.