ATI : immune system

When caring for a patient who is receiving vincristine to treat lung cancer, the HCP should monitor for which of the following findings that indicates an adverse effect?
Weak hand grasps

Vinca alkaloid can cause peripheral neuropathy. The health care profession should monitor deep- tendon reflexes and the strength and movement of the hands and feet.

A HCP is about to administer enfuvirtide (Fuzeon) to a patient. The HCP should perform which of the following actions?
– Administer the drug SubQ
– Roll the vial gently to reconstitute the solution
– Inject the solution at room temperature

A HCP should understand that raltegravir (Isentress) treats patients who have which of the following?
Resistant HIV disease

While assessing a patient who is receiving interfreon alfa-2a (Roferon-A) to treat Kaposi’s sarcoma, the HCP should check for which of the following possible indications of an adverse reaction?
Fever: Interferon can cause flu like reaction, fever, fatigue. Should give acetaminiphen.

A HCP is caring for a patient who is about to begin taking intrathecal cytarabine (DepoCyt) therapy to treat meningeal leukemia. Reduce risk of neurotoxicity?
Dexamethasone, a glucocorticoid to help decrease inflammation of the arachnoid that the drug can cause. IV dexamethasone reduces the patients risk for neurotoxicity.

Cisplatin adverse reactions
treat testicular cancer; paresthesias, sore throat, flank pain, and tinnitus are adverse effects

delavirdine (Rescriptor)
treat HIV-1; non-nucleoside reverse transcriptase inhibitor; can cause a rash; can develop into Stevens-Johnson syndrome

carmustine (BiCNU)
treat multiple myeloma; nitrosourea drug; can cause delayed bone marrow suppression; greatest risk for infection 4-6 weeks after infusion

trastuzumab (Herceptin)
treat metastatic breast cancer; wheezing, dysrhythmias, hypotension, and fever are adverse reactions

mercaptopurine (Purinethol)
treat leukemia;

* use contraception
* perform oral hygiene frequently
* perform hand hygiene frequently
^ avoid activities that can cause injury

A HCP should question the use of anastrozole (Arimidex) for a patient who is
Premenopausal: aromatase inhibitor, treats early or advanced estrogen receptor.

Vincristine therapy
treat lymphoma, increase fiber intake. Vincristina: Vinca alkaloid- can cause severe constipation and upper colon fecal impaction.

treats prostate cancer; androgen receptor blocker; monitor for gynecomastia: growth of breast tissue, decreased libido, and impotence.

maraviroc (Selzentry)
chemokine receptor 5 antagonist; can cause paresthesias, cough and upper respiratory infection, liver damage, fever and sinus infection; contraindicated for those who do not have CCR5-tropic HIV-1


start ritonavir (Norvir) and zidovudine (Retrovir)
treat HIV-1; prevents drug resistance

action to take when giving paclitaxel (Taxol) for ovarian cancer
give antihistamine
* administer through non-PVC tubing
* use an in-line filter

topotecan (Hycamtin)
treat resistant small-cell lung cancer; caution taking NSAIDs, anticoagulants, and antiplatelet drugs; increases patient’s risk for bleeding while taking topotecan a topoisomerase inhibitor

nitrogen mustard; contraindicated for patients who have a fluid-volume deficit because dehydration increases risk for renal toxicity

methotrexate (Trexall)
non-Hodgkin lymphoma; folic acid antagonist; can cause severe bone marrow suppression with decreased thrombocyte counts and also oral and GI ulceration; use a soft-bristled toothbrush to prevent bleeding and mouth trauma

imatinib (Gleevec)
targeted antineoplastic drug; can cause bone marrow suppression; clean fruits and veggies to prevent transmission of bacteria; weigh self daily; can cause fluid retention; perform hand hygiene frequently; avoid herbal supplements; St. John’s wort can decrease imatinib levels

tamoxifen (Soltamox)
breast cancer; estrogen-receptor blocker; can cause retinopathy, cataracts, and decreased visual acuity

When considering drug therapy options for a patient who has metastic breast cancer that is positive for human epidermal growth factor receptor 2 (HER2), HCP should choose
Trastuzumab (herceptin): antibody and pregnancy risk category D, treats metastic breast cancer with tumors that over express.

Which immunixation should adults receive once a year?
Influenza: seasonal influenza. All children 6 months or older should too.

Advanced HIV disease.

When caring for a patient who is receiving vincristine to treat lung cancer, the health care professional should monitor for which of the following findings that indicates an adverse effect? Weak hand grasps A health care professional is about to …

Types of Cancer – Carcinomas: epithelial tissue: skin and mucous membranes that line lungs and GI tract – Sarcomas: connective tissue: muscle, bone, cartilage – Leukemias: blood-forming tissue: bone marrow – Lymphomas: immune system Reproductive Cycle of a Cell G1: …

Life Cycle of a RetroVirus 1. Virus binds to CD4-T cell -Fusion to lipid membrane -Tightens by coreceptors CCR5/CXCR4 -Virus enters CD4-T cell -Reverse transcriptase converts HIV RNA to HIV DNA 2. Enzyme integrase combines HIV DNA with the cells …

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Natural Immunity • Present at birth • Protection provided by physical barriers: • Skin, mucus membranes • Phagocytic cells • NK cells Specific Acquired Immunity • Production of antibodies against antigens Active: • Having the infection or a vaccine / …

A health care proffesional is caring for a patient who is about to begin taking INH to treat tb. The health care professional should tell the patient to report which of the following adverse effects of the drug? Select all …

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