mast cell degranulation
bronchial smooth muscle constriction
increased mucous secretion and mucosal edema
exp. wheezing most common
leukotriene modifiers and mast cell stabilizers
use with an inhaled corticosteroid.
not commonly prescribed any longer due to narrow theraputic index and wide absorption range
has a massive side effect profile
2. eliminate irritants
3. flu shot yearly
4. pneumonia vaccine as indicated
5. symptomatic therapy
primary symptom is chronic productive cough (will have foul odor if not on ABX).
Clubbing of fingers common
Can lead to pulmonary edema.
can lead to perm. lung damage d/t compartmentalizing of the effected areas (cavatation)
asbestos, talc, clay, cement, coal, silica
increased mucous production of thicker mucous
panacinar- entire acinus destruction, more sporadic, older population and alpha1-antitrypsin deficiency.
Small cell- excessive hormone secretion is indicated in 40% of cases. Mets early. Strongly associated with smoking.